Beilstein J. Nanotechnol.2022,13, 538–548, doi:10.3762/bjnano.13.45
PHEG-Tyr (Figure 6a, crosses) was tested. Interestingly, it was found that these polypeptide nanogels also showed an inhibition effect on trypsin. The results indicate that these nanogels synthesized from Nα-Lys-NG or PHEG-Tyr polypeptide precursors, in other words from synthetic poly(aminoacid)s
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Figure 1:
TEM images of PHEG-Tyr (a) and Nα-Lys-NG (b) nanogels prepared by HRP/H2O2-mediated crosslinking in...
Beilstein J. Nanotechnol.2019,10, 2579–2593, doi:10.3762/bjnano.10.249
, Nagyvarad square 4, Budapest, Hungary 10.3762/bjnano.10.249 Abstract Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(aminoacid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis
backbone determines almost all of the properties of the hydrogels. For biological applications, in general, the polymer backbone and its degradation products have to be biodegradable and biocompatible [11][23]. In contrast to many synthetic polymers, the degradation products of poly(aminoacid)s, which are
mainly built from only one or two types of amino acids, are biocompatible nutrients. In addition, poly(aminoacid)s have enormous structural diversity and they supposedly lack immunogenicity [24][25]. In summary, the use of poly(aminoacid)s has practically only one disadvantage: their synthesis is
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Figure 1:
Synthesis of the simultaneously cross-linked and thiolated PSI and PASP gels.